COVID-19 causes a variety of symptoms, including fever, cough, and olfactory and taste disorders 2. SARS-CoV-2 infects the host by invading cells via angiotensin-converting enzyme 2 (ACE2) 1. A large-scale, long-term cohort study is desired.Ĭoronavirus disease 2019 (COVID-19) is an illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study revealed the significant impacts of Long COVID on health in local communities. Experiences of stigma and discrimination were reported by 43.3% of participants. Of all participants, 29.1% had possible impairments in work performance. Female sex and the presence of sequelae were independent risk factors for psychological distress. Possible psychological distress was noted in 30.7% (17.9% of males and 45.0% of females). Multivariate analysis showed that age was an independent risk factor for sequelae (adjusted odds ratios for ≥ 60 years vs. < 40 years 3.63, p = 0.0165). The most frequent symptoms were olfactory disorders (15.0%), taste disorders (14.2%), and cough (14.2%). Among patients with mild COVID-19, 49.5% had sequelae.

Among 127 patients who had recovered from COVID-19, 52.0% had persistent symptoms at a median of 29 days after COVID-19 onset. Factors independently associated with sequelae or psychological distress were identified using logistic regression analysis. The prevalence of sequelae was calculated by age and COVID-19 severity. We conducted a self-administered questionnaire survey on sequelae, psychological distress (K6), impairments in work performance (WFun), and COVID-19–related experiences of stigma and discrimination in two designated COVID-19 hospitals in Hiroshima Prefecture, Japan, between August 2020 and March 2021. This cross-sectional study aimed to investigate the post-acute consequences of COVID-19.

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